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KMID : 1140120100150010060
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Cancer Prevention Research
2010 Volume.15 No. 1 p.60 ~ p.68
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The Effects of Anthocyanins on VEGF-Mediated Angiogenesis
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Kim Kun-Do
Kim Hwa-Mi
Kim Chi-Yeon
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Abstract
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Angiogenesis, the process of new blood vessel growth from pre-existing capillaries, is involved in physiological and pathological processes such as tumor growth and metastasis. Thus, suppression of abnormal angiogenesis may provide therapeutic strategies for the treatment of angiogenesis-dependent disorders, like as skin cancer, psoriasis, and other reactive skin disorders. There is increasing evidence that polyphenols found in natural products may have a beneficial preventive effect on cardiovascular disease and cancer by mechanisms including factor of angiogneisis that have not yet been elucidated. In the present study, we investigated the antiangiogenic activities of anthocyanin, a class of polyphenols
present at high levels in dietary black bean, in both in vitro and in vivo models. In vitro studies were performed using cultured human umbilical vein endothelial cells (HUVEC). After inducing angiogenesis by vascular endothelial cell growth factor (VEGF) on those cultured cells, we analyzed dose-dependent changes before- and after-anthocyanin treatment. In vivo, Chorioallantoic membrane (CAM) assay was done to check developmental effect on embryo vasculature. Dietary anthocyanin from black bean had statistically significant inhibitions on endothelial cell migration and tube formation in dose dependant manner, and also inhibited embryological vascular development. We suggest that an anthocyanin derived
from diet has a natural VEGF inhibitor that could potentially be useful in cancer prevention and/or treatment
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KEYWORD
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Angiogenesis, Chemotherapy, HUVEC, Pro-angiogenic factor
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